Editorial Perspectives: will SARS-CoV-2 reset public health requirements in the water industry? Integrating lessons of the past and emerging research
考夫曼和同事加雷思?哈里斯(Gareth Harris)发现，居住在那些人种快速多样化地域的英国白人更倾向于投给右翼的英国国家党(British National Party)。宾夕法尼亚大学政治学教授丹尼尔?霍普金斯(Daniel Hopkins)在美国发现了相似的民族变化导致反移民政策的规律。
Editorial Perspectives: 2019 novel coronavirus (SARS-CoV-2): what is its fate in urban water cycle and how can the water research community respond?
One of the more notorious incidents was when Zhu Ling, a student at the prestigious Tsinghua University, was paralyzed when her roommate allegedly poisoned her with thallium in 1994.
Nano and biosensors for detection of SARS-CoV-2: challenges and opportunities
Soft matter science and the COVID-19 pandemic
Carbon-based antiviral nanomaterials: graphene, C-dots, and fullerenes. A perspective
By turns breathtaking, hilarious and disturbing, Jonathan Glazer’s extraordinary, erotic film achieves a rare blend of fantasy and realism
Ultraviolet-C and other methods of decontamination of filtering facepiece N-95 respirators during the COVID-19 pandemic
Make sure you've got a good plan for seeing that your children are cared for when you're scheduled to be in class, and when you need to study. It really is possible to raise children while you're going to school. People do it every day.
“In the drama, romance is the protagonist’s only pursuit. It seems that the meaning of her life is to have a romantic relationship with a Prince Charming. No, not only one, but three or four,” Douban user Jiuyuehuashang said.
Trends and targets in antiviral phototherapy
Coca-Cola (KO, Fortune 500) Chief Executive Muhtar Kent thinks as both a first-generation American as well as a business leader that immigration reform is good for business. Kent outlined in a February USA Today op-ed how "lucky" he felt to be able to make his life in the U.S. and his belief that foreign entrepreneurs should have the same opportunity. The CEO wrote that he supports immigration reform because immigration is "an essential part of the growth calculus for this great country."
5. bedazzled / a . 眼花缭乱的。
Two colors! It may not sound revolutionary, but everything is relative. And know this: It’s not about indecision, but social progress. That’s Pantone’s position, anyway.
A new point-of-care test for the diagnosis of infectious diseases based on multiplex lateral flow immunoassays
本周二，年仅17岁的Thomas Sohmers推出了一个全新的高速计算机服务器，该计算机功耗极低，该计算机使用了低能耗的ARM处理器，而其所需电量仅为一台普通电脑一小部分。在本周在旧金山举行的Open Compute Project (OCP)大会上，Sohmers展示了这台服务器。这个产品是Sohmers所创办的企业REX所推出的第一个产品，REX的另一位创始人为52岁的Kurt Keville，目前Keville担任公司的CTO。
Novel biosensing methodologies for ultrasensitive detection of viruses
Anti-tumor, -viral, and -bacterial activities of polyoxometalates for realizing an inorganic drug
迷你剧集/电影类最佳男演员：考特尼?B?万斯(Courtney B Vance)，《美国罪案故事：公诉辛普森》(The People v. O. J. Simpson: American Crime Story)
“Selling out!” “Pandering to the Americans!” The cries went up immediately when the official selection was announced. The list of directors crossing over to make films in English was a long one including the Italians Matteo Garrone and Paolo Sorrentino, Yorgos Lanthimos of Greece, Norway's Joachim Trier and even Guillaume Nicloux of France, a country whose cultural establishment is highly sensitive to the creeping Anglophone menace. The argument goes that Cannes is supposed to be a haven for world cinema; for English, there is Hollywood. But does it really matter? Films at Cannes in languages other than French or English play with subtitles in both languages – and that's a lot of text to deal with.
ACE2 as a potential therapeutic target for pandemic COVID-19
Diagnostic technologies for COVID-19: a review
City on the Silk Road
Targeting severe acute respiratory syndrome-coronavirus (SARS-CoV-1) with structurally diverse inhibitors: a comprehensive review
The Brexit trade uncertainty
8. Ford Motor
An overview of key potential therapeutic strategies for combat in the COVID-19 battle
Julian Evans-Pritchard, China economist at Capital Economics, commented:
Potential repurposed SARS-CoV-2 (COVID-19) infection drugs
The joint programme delivered by IQS of Spain, Fu Jen Catholic University in Taiwan and the University of San Francisco saw the biggest rise. Its Master in Global Entrepreneurship Management jumps 34 places to 43rd, making up for a drop of 19 places the previous year. The only programme to be delivered on three continents, it is ranked top for international course experience.
Nature as a treasure trove of potential anti-SARS-CoV drug leads: a structural/mechanistic rationale
Atlas Wearables founder Peter Li says battery technology and user retention are two more obstacles facing the wearables market. Some use cases require significant improvements to battery technology for a compelling experience, he says, and there’s always a balance to be struck between wear time between charges and processing power and features.
In search for effective and definitive treatment of herpes simplex virus type 1 (HSV-1) infections
This is a thorny issue that’s unique to messaging apps. We expect ads to live alongside content we consume. We don’t expect them to crop up in our one-on-one communications. “The last thing you want in a personal conversation is a banner ad or pop-up that interrupts that,” Wray says. “It might work with more impersonal networks, but specifically within messaging, people hate traditional ads.”
Antiviral drug discovery: broad-spectrum drugs from nature
在出售给Facebook前，WhatsApp一直特别反对植入广告。该公司首席执行官让o库姆在自己桌上一直贴着联合创始人布莱恩o阿克顿留下的一张便条，随时提醒自己牢记公司的核心价值观：“不要广告！不要游戏！不要宣传噱头！”这样一来，短信应用只好想出别的创意。比如Tango就在用户的短信“收件箱”里插入广告。中国互联网巨头腾讯公司旗下的短信应用——微信，则通过游戏、贴纸（类似于表情符号）和移动购物等方式谋取赚钱之道。Kik则提供一种被一些人称为“聊天广告”的功能，用户通过它能和幽默网站Funny or Die及电影信息网站Moviefone这类品牌运营的聊天程序进行交谈。
The Fed last month laid out a timetable to slow the pace of its bond purchases throughout the year. The central bank, which had been soaking up $85 billion a month in Treasurys and mortgage-backed securities since late 2012, plans to reduce the pace of purchases by $10 billion at each meeting until it is no longer buying bonds at year-end.
Influenza neuraminidase: A druggable target for natural products
"Even though these two researchers worked independently of one another, the combination of Shapley's basic theory and Roth's empirical investigations, experiments and practical design has generated a flourishing field of research and improved the performance of many markets," the academy said.
《患难与共》(Togetherness)，HBO，1月11日播出。HBO台的周日晚间喜剧组合中已经有了20出头的纽约女人（《都市女孩》[Girls]第四季第一集将在同一天晚上播出），还有快到30岁的旧金山男同性恋（《寻》[Looking]也在当天开播第二季）。现在又来了30多岁的洛杉矶异性恋者们。这部有点阴郁的半小时喜剧来自杰伊(Jay)和马克·杜普拉斯(Mark Duplass)，兄弟俩曾经合拍过《肥大的椅子》(The Puffy Chair)和《纸袋头》(Baghead)等诡异的电影。马克·杜普拉斯和梅兰妮·林斯基(Melanie Lynskey)饰演一对夫妻，和杜普拉斯最好的朋友（史蒂夫·齐西斯[Steve Zissis]饰演）与林斯基的姊妹（阿曼达·皮特[Amanda Peet]饰）合住一栋房子。
“Our population and employment is at an all-time high and growing. That puts significant pressure on rents and prices,” said Mark Willis, the executive director of the New York University Furman Center for Real Estate and Urban Policy. “There is no reason now to think that these trends are likely to change.”
China, the world’s most populous country, ranks No. 20 overall. It is considered to be the third most powerful nation and the second best country in which to start a business.
Emerging investigators series: the source and fate of pandemic viruses in the urban water cycle
The role of biosensors in the detection of emerging infectious diseases
7. “The Kindergarten Teacher” In his tough, weird knockout, the Israeli director Nadav Lapid spins the story of a teacher’s obsession with a child poet to create a savage portrait of fanaticism and its costs.
Quantitative determination of mechanical stability in the novel coronavirus spike protein
For those outside the scientific community, the response to the retraction has been mixed.
Interaction of hydroxychloroquine with SARS-CoV2 functional proteins using all-atoms non-equilibrium alchemical simulations
"I'm not really worried about it, honestly," Bryant said. "My shooting will be better."
But the carriers are having a more difficult time over the winter holidays. About 30 percent of winter holiday flights were delayed in 2012, on top of significant delays in 2011 and 2010. You can check holiday flight statistics from the Transportation Department on its website.
MPLEx: a method for simultaneous pathogen inactivation and extraction of samples for multi-omics profiling
The workers, who were part of a crew building a football stadium, were taken in the mainly Shi'ite Habibiya district in northeastern Baghdad.
Multicolored silver nanoparticles for multiplexed disease diagnostics: distinguishing dengue, yellow fever, and Ebola viruses
戈尔迪·霍恩（Goldie Hawn）曾因影片《仙人掌花》（Cactus Flower）获最佳女配角奖，她的奖杯坐落在一个非常富有禅宗气息的地方——她的“印度房间”，她常在这里冥想。她的小金人并不是唯一一个和主人有共鸣的奖杯，罗素-克洛（Russell Crowe）曾在影片《角斗士》（Gladiator）中身着罗马战士裙装，扮演了一个威猛、极具感情和个性的古罗马战士--司令官马克西姆斯，他的奖杯放在鸡舍中，因为克洛相信小金人能够保佑母鸡下出更大的鸡蛋。
Inhibition of SARS coronavirus helicase by bismuth complexes
The attitude of the founder will set the tone for the business. Negativity, laziness and entitlement waste time and money while they tarnish your reputation. Success largely depends on making mistakes and accepting blame in stride. Owning up to and facing challenges head-on is what makes a mere business owner a leader.
Not until recently anyway. But scientists at Weill Cornell Medical College have at last managed to—at least with mice and monkeys. This produced artificial retinas, whose chips convert images into electronic signals and whose tiny projectors convert electronic signals into light.
Goldie Hawn’s award for best supporting actress in the 1970 film Cactus Flower rests somewhere altogether more zen – in the “India Room” in which she likes to meditate. Hers isn’t the only award to apparently emit good vibes – Russell Crowe’s award for best actor, which he won for his role as the bang-on-trend, leather miniskirt clad Maximus Decimus Meridius in Ridley Scott’s 2000 film Gladiator, is kept in a chicken coop on the actor’s Australian ranch. Crowe apparently thinks it helps the hens lay bigger eggs.
Unveiling the molecular mechanism of SARS-CoV-2 main protease inhibition from 137 crystal structures using algebraic topology and deep learning
The unemployment rate probably won't fall quite as rapidly in 2015, according to economists, especially if more people enter the labor force because jobs are easier to find. Yet another large spate of hiring similar to the gain in 2014 would make the low unemployment rate more believable.
A serological aptamer-assisted proximity ligation assay for COVID-19 diagnosis and seeking neutralizing aptamers
The world is casting its eye on Brazil for hosting two of the most coveted sporting events — the 2014 FIFA World Cup and the Summer Olympics two years after. Except for watching exciting games and cheering for your favorite team and players, you can also take a trip to “the lungs of the earth”, the Amazon forest, to escape the crowds and embrace nature. Either way, Brazil is sure to leave you with an unforgettable memory.
Revealing the molecular mechanisms of proteolysis of SARS-CoV-2 Mpro by QM/MM computational methods
The molecular mechanism of the proteolysis reaction catalyzed by SARS-CoV-2 Mpro, one of the enzymes essential for the replication process of the virus responsible for the COVID-19 pandemic, is described using computational QM/MM methods.
Multi-targeting of functional cysteines in multiple conserved SARS-CoV-2 domains by clinically safe Zn-ejectors
By combining evolutionary and physico-chemical principles, previously unknown druggable Zn-sites in multiple conserved SARS-CoV-2 domains have been identified.
Computer-generated “synthetic contingency” plans at times of logistics and supply problems: scenarios for hydroxychloroquine and remdesivir
“An employee baked a cake with her resignation letter written on top.”
Engineered unnatural ubiquitin for optimal detection of deubiquitinating enzymes
The Chinese-made 3D fantasy/adventure film "Monster Hunt" broke a string of box-office records on its release in the country in July 2015, becoming the highest grossing film of the year in the Chinese mainland.
A Digital Protein Microarray for COVID-19 Cytokine Storm Monitoring
Accelerating the repurposing of FDA-approved drugs against coronavirus disease-19 (COVID-19)
10. The difference between a lie and a promise is that the believer of a lie is the listener and the believer of a promise is the speaker.
A point-of-care selenium nanoparticle-based test for the combined detection of anti-SARS-CoV-2 IgM and IgG in human serum and blood
Assessing potential inhibitors of SARS-CoV-2 main protease from available drugs using free energy perturbation simulations
Until now, the appeal of Bigcommerce’s eponymous technology has been simplicity and its ability to scale along with merchants as they grow. “To some, this will mean the difference between success and failure,” said Steve Case, who as a board member advises Bigcommerce on U.S. entrepreneurial trends. “Even just five years ago, if you wanted to create a compelling offering, it could cost hundreds of thousands of dollars. Now, you can get up and running in hours for less than $100 per month.”
The inactivation mechanism of chemical disinfection against SARS-CoV-2: from MD and DFT perspectives
Switzerland debuts as the No. 1 Best Country in 2017. The country, well-known for its history of neutrality, ranks No. 3 in Open for Business and No. 3 in Citizenship.
London Business School is top of the 2014 FT ranking of European business schools, regaining the position it last held in 2005. LBS pushed the 2013 joint winners HEC Paris and Spain’s IE Business School into second and third places respectively.
The PR industry excelled itself with increasingly fancy descriptions for the basic activities of emailing, talking and meeting. Entrants included: “I want to jump on your radar” (a bad idea, as if you jump on radars they break) and “let’s find a time to connect to mutually update”. My favourite came from a PR man named Michael who wrote: “I hope you don’t mind the outreach.” Alas, I do mind. To reach out has always been hateful, but making it a noun, and reversing the word order, does not help. Michael, you’ve won the Communications cup.
Antiviral agents against COVID-19: structure-based design of specific peptidomimetic inhibitors of SARS-CoV-2 main protease
There is a natural human tendency to idealize and whitewash days of yore, to cast them in the rosy glow of the mind’s eye.
Pharmacophore-based approaches in the rational repurposing technique for FDA approved drugs targeting SARS-CoV-2 Mpro
Taken alongside data released in the past few days, and it doesn't make things easier. The country is still struggling with deflation and household spending slumped last month. But retail sales data released this morning topped estimates.
Amino acid interacting network in the receptor-binding domain of SARS-CoV-2 spike protein
在上榜的90所欧洲商学院中，法国的欧洲工商管理学院(Insead)在全日制MBA课程和EMBA课程方面居首，瑞士圣加伦大学(St Gallen)的管理硕士课程排名第一。西班牙Iese商学院(Iese Business School)和瑞士洛桑国际管理发展学院(IMD)分别在定制和开放注册高管教育课程上夺魁。
Greener liquid-phase synthesis and the ACE inhibitory structure–activity relationship of an anti-SARS octapeptide
Fereston recalls when writer Jennifer Crittenden stopped him in the hallway after filming and asked him, 'Are you sure about this? Are you sure you're not ruining Julia Louis-Dreyfus' career?' Considering Dreyfus won an Emmy that same year, it's safe to say the dance was a good career move for the actress. And now to reminisce, here is Elaine doing her famous "Elaine Dance."
Master of None
Anti-inflammatory, antiallergic and COVID-19 protease inhibitory activities of phytochemicals from the Jordanian hawksbeard: identification, structure–activity relationships, molecular modeling and impact on its folk medicinal uses
The biomaterial polyphosphate blocks stoichiometric binding of the SARS-CoV-2 S-protein to the cellular ACE2 receptor
There was no indication of the identity of the kidnappers or their motive.
I said it last year - and I'll say it again. There is only one activity more thankless than predicting the future - and that is publicly sharing your predictions.
Ilimaquinone (marine sponge metabolite) as a novel inhibitor of SARS-CoV-2 key target proteins in comparison with suggested COVID-19 drugs: designing, docking and molecular dynamics simulation study
他们两个自称拥有着世界上最大的两个粉丝基础。但是周日晚上，在伦敦温布利SSE竞技场上举行的2017年欧洲音乐大奖中，Shawn Mendes夺得桂冠， Taylor Swift在她参选的五个奖项中纷纷落选。
Design and optimization of a subunit vaccine targeting COVID-19 molecular shreds using an immunoinformatics framework
Songs (Ping An, Xu Yina and Apusasa)
About 40 per cent of entrepreneurs derive most of their income from their company with an average salary of about $194,000 compared to $171,000 for non-entrepreneurs. Entrepreneurs in Asia/Oceania seem to be the most successful. Nearly half (48 per cent) of them earn most of their income from their company and earn the highest salary ($251,000 on average), just ahead of those based in the Middle-East ($244,000).
Several coumarin derivatives and their Pd(II) complexes as potential inhibitors of the main protease of SARS-CoV-2, an in silico approach
Coumarin derivatives and their Pd(II)-complexes have shown a higher binding potential towards SARS-CoV-2 Mpro than chloroquine/cinanserin along with lower toxicity.
Carotane sesquiterpenes from Ferula vesceritensis: in silico analysis as SARS-CoV-2 binding inhibitors
Sesquiterpenes, 8α-anisate-dauc-4-ene-3,9-dione (webiol anisate) (1) and 10α-acetoxy-6α-benzoate-jaeschkeanadiol (2) as well as several analogues (3–12) were root extracted from Ferula vesceritensis.
Quinazoline-Schiff base conjugates: in silico study and ADMET predictions as multi-target inhibitors of coronavirus (SARS-CoV-2) proteins
Design of 2-phenylquinazolin-4(3H)one-trihydroxyphenyl Schiff base conjugates as COVID-19 therapy.
Automated multiplex nucleic acid tests for rapid detection of SARS-CoV-2, influenza A and B infection with direct reverse-transcription quantitative PCR (dirRT-qPCR) assay in a centrifugal microfluidic platform
Beijing targets consumer prices inflation at 3.5 per cent, but weakening growth is keeping prices benign.
“An interviewer walked inta closet instead of the meeting room.”
A modular microarray imaging system for highly specific COVID-19 antibody testing
Development of a tablet PC-based portable device for colorimetric determination of assays including COVID-19 and other pathogenic microorganisms
But I expect other banks to follow suit. Any effort to keep good people fresh and engaged, without paying them more, should be up for consideration.
Inhibition of SARS-CoV-2 main protease by phenolic compounds from Manilkara hexandra (Roxb.) Dubard assisted by metabolite profiling and in silico virtual screening
“LBS has broadened my profession horizons and opened international career opportunities,” said one graduate. He added: “In the three years after graduation I have worked in the US, Canada and Hong Kong, while rotating in different businesses from corporate banking to debt capitalmarkets”.
Rapid prediction of possible inhibitors for SARS-CoV-2 main protease using docking and FPL simulations
A combination of Autodock Vina and FPL calculations suggested that periandrin V, penimocycline, cis-p-Coumaroylcorosolic acid, glycyrrhizin, and uralsaponin B are able to bind well to SARS-CoV-2 Mpro.
Curcumin to inhibit binding of spike glycoprotein to ACE2 receptors: computational modelling, simulations, and ADMET studies to explore curcuminoids against novel SARS-CoV-2 targets
Swyft now makes half of its money from ad campaigns like the one for Gwen Stefani. Swyft’s revenue has increased between 50% and 100% each month, Wray says. The other half comes from selling stickers—typically licensed from sports teams and entertainment brands like Shrek.
They are also less likely to seek employment in a different sector after graduation. Only 30 per cent changed industry sector compared with nearly two-thirds of full-time MBA students.
A density functional theory study on silver and bis-silver complexes with lighter tetrylene: are silver and bis-silver carbenes candidates for SARS-CoV-2 inhibition? Insight from molecular docking simulation
The government's next snapshot of the job market, due Friday, will be distorted by Sandy, which devastated the Northeast in late October, leaving many jobless. Economists say Sandy could temporarily knock anywhere from 100,000 to 150,000 off of the government's jobs tally for November, resulting in job growth of under 100,000 or even much less.[qh]
An in silico perception for newly isolated flavonoids from peach fruit as privileged avenue for a countermeasure outbreak of COVID-19
3′-Hydroxy-4′-methoxy-chroman-7-O-β-D-glucopyranoside 4, together with three known compounds, ferulic acid heptyl ester 1, naringenin 2, and 4,2′,4′-trihydroxy-6′-methoxychalcone-4′-O-β-D-glucopyranoside 3, was isolated from peach fruits.
Understanding the role of galectin inhibitors as potential candidates for SARS-CoV-2 spike protein: in silico studies
By turns breathtaking, hilarious and disturbing, Jonathan Glazer’s extraordinary, erotic film achieves a rare blend of fantasy and realism
Characterization of a commercially-available, low-pressure UV lamp as a disinfection system for decontamination of common nosocomial pathogens on N95 filtering facepiece respirator (FFR) material
"Hong Kong is a small island with 7 million people ... and you have 1.5 billion across the border (in mainland China) who would like to invest," Mark Elliott, associate director of International Residential Property Services at Jones Lang LaSalle, tells CNN. "The government is releasing more and more land, but it doesn't work."
A facile assay for rapid detection of COVID-19 antibodies
Potential role of medicinal plants and their constituents in the mitigation of SARS-CoV-2: identifying related therapeutic targets using network pharmacology and molecular docking analyses
2.Show Up, Every Time
Apple was the only top five PC maker to see shipments grow last year, up over 6%, while Acer saw the biggest fall, of more more than 18%.
Remdesivir-bound and ligand-free simulations reveal the probable mechanism of inhibiting the RNA dependent RNA polymerase of severe acute respiratory syndrome coronavirus 2
Consensus virtual screening of dark chemical matter and food chemicals uncover potential inhibitors of SARS-CoV-2 main protease
Clinical decision support tool and rapid point-of-care platform for determining disease severity in patients with COVID-19
Bingo! In fewer than 20 words it combined five previous years’ winners, only to say nothing at all. With a heavy heart, I award eBay my overall Golden Flannel Award for 2016.
No.1: Einstein Alive Again?
Whole-genome sequence analysis and homology modelling of the main protease and non-structural protein 3 of SARS-CoV-2 reveal an aza-peptide and a lead inhibitor with possible antiviral properties
Molecular docking reveals the potential of Salvadora persica flavonoids to inhibit COVID-19 virus main protease
Molecular docking reveals the potential of Salvadora persica flavonoids to inhibit COVID-19 virus main protease.
Smartphone-based multiplex 30-minute nucleic acid test of live virus from nasal swab extract
The ranking of 95 schools, up from 90 last year, includes nine institutions, from seven countries, that were ranked for the first time. Frankfurt School of Finance and Management in 41st place is the year’s highest new entrant. The German school has one of the most gender-balanced programmes, with women accounting for 49 per cent of students.
Anti-HIV drug repurposing against SARS-CoV-2
3.Good problem solver
But as economic growth slows in China, institutional investors from further afield say the city’s property market has overheated and is entering a correctional phase.
Length-scale dependence of protein hydration-shell density
Dealers: Car dealers work toward reducing the paperwork involved in buying a car and the hours it takes to fill it out. That will give them more time to devote to upselling add-ons such as extended warranties, paint and fabric protection, and rust-proofing.
In 2016, we've seen a whole lot of new gadgets join the Internet of Things (unfortunately, we've also seen them harnessed by hackers to bring downhuge swaths of the internet). From appliances to clothing, companies really want to sell you the tech that'll make your life "smarter," but sometimes it just makes it slower and dumber. Let's look back on some of the most ridiculous and useless internet-connected gadgets that were produced in the past 12 months.
A major disruption still could push oil higher, but potential oversupply makes even that less likely. Emerging-market demand once kept supply so tight that any disruptions led to striking price moves, said Ole Hansen, head of commodity strategy at Saxo Bank.
High antiviral activity of mercaptoethane sulfonate functionalized Te/BSA nanostars against arterivirus and coronavirus
A handheld continuous-flow real-time fluorescence qPCR system with a PVC microreactor
Jobs for workers with branding skills were also on the rise during the third quarter of 2016, most likely thanks to “small businesses’ need to create cohesive and consistent strategies for their companies online,” according to the report.
PC demand has been hit by competition from smartphones and tablets, along with longer lifecycles for PCs. Shipments fell in all regions around the world and have declined for five quarters in a row, according to IDC's figures.
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